Akihiko Taguchi
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氏名Name
Akihiko Taguchi
所属・職名Affiliation, Title, etc.
Department of Regenerative Medicine Research
Institute of Biomedical Research and Innovation at Kobe
Professor
研究室HPWebsite
一言メッセージShort Message
We believe it is possible to regenerate neural function of patients with dementia or cerebral infarction.
本プロジェクトでの研究概要Outline of the research in this project
Application of stem cell therapy for dementia with elucidation of its mechanism of action
We had reported that (1) hematopoietic stem cell (HSC) transplantation for stroke mice promotes angiogenesis and neurogenesis, (2) autologous HSC transplantation for stroke patients promotes neurological functional recovery, (3) HSC transplantation for aged dementia mice activates neurogenesis at hippocampus followed by improvement of cognitive function, and (4) the basic mechanism of action of HSC transplantation is the activation of glycolytic ATP production in damaged cells through gap junction-mediated direct cell-cell interaction.
In this project, we will (1) elucidate the detailed mechanism of the effects of HSC on activation of glycolytic ATP production via gap junction, and (2) develop novel therapy using HSC for patients with dementia.
これまで主な研究内容Outline of main research so far
(1) Stem cell transplantation improves neurogenesis in murine stroke model
We have found that hematopoietic stem cell (HSC) transplantation after stroke enhances cerebral angiogenesis, and the angiogenesis is essential for endogenous neurogenesis after stroke.
(2) Stem cell transplantation improves neurological recovery in patients with stroke
We conducted a clinical trial of autologous HSC transplantation for patients with severe stroke. We have found that HSC transplantation improves functional recovery with increased cerebral metabolism.
(3) Stem cell transplantation improves neurogenesis in murine dementia model
We have revealed HSC transplantation for aged dementia mice activates neurogenesis at hippocampus followed by improvement of cognitive function.
(4) Identification of the mechanism of action of stem cell therapy
We have revealed that the mechanism of action of HSC is direct cell-cell interaction via gap junctions.
主な経歴・受賞歴等Career, Awards, etc.
- 1989
- Clinical resident. Osaka University Hospital
- 1990
- Clinical Fellow, Department of Strokology. Hoshigaoka Koseinenkin Hospital
- 1993
- Doctoral Program, Department of Neuroscience. Osaka University Graduate School of Medicine
- 1996
- Postdoctoral Fellow, Department of Physiology. Columbia University
- 2000
- Clinical Fellow, Department of Cardiology and Strokology. Osaka Minami National Hospital,
- 2002
- Laboratory Chief, Laboratory of Cerebral Circulation and Metabolism. National Cerebral and Cardiovascular Center
- 2011
- Professor, Department of Regenerative Medicine. Institute of Biomedical Research and Innovation at Kobe
主要業績Major Publications
Okinaka Y, Maeda M, Kataoka Y, Nakagomi T, Doi A, Boltze J, Claussen C, Gul S, Taguchi A. Direct Water-Soluble Molecules Transfer from Transplanted Bone Marrow Mononuclear Cell to Hippocampal Neural Stem Cells. Stem Cells Dev. 2024 Sep;33(17-18);505-51. doi: 10.1089/scd.2024.0043
Okinaka Y, Shinagawa Y, Claussen C, Gul S, Matsui I, Matsui Y, Taguchi A. RNA analysis of circulating leukocytes in patients with Alzheimer's disease. J Alzheimers Dis. 2024;97(4):1673-1683.
Houkin K, Osanai T, Uchiyama S, Minematsu K, Taguchi A, Maruichi K, Niiya Y, Asaoka K, Kuga Y, Takizawa K, Haraguchi K, Yoshimura S, Kimura K, Tokunaga K, Aoyama A, Ikawa F, Inenaga C, Abe T, Tominaga A, Takahashi S, Kudo K, Fujimura M, Sugiyama T, Ito M, Kawabori M, Hess DC, Savitz SI, Hirano T. Allogeneic Stem Cell Therapy for Acute Ischemic Stroke: The Phase 2/3 TREASURE Randomized Clinical Trial. JAMA Neurol. 2024 Jan 16:e235200.
Yasui K, Ogawa Y, Saino O, Akamatsu R, Fuchizaki A, Irie Y, Nabetani M, Tanaka M, Takihara Y, Taguchi A, Kimura T. X-irradiated umbilical cord blood cells retain their regenerative effect in experimental stroke. Sci Rep. 2024 Mar 22;14(1):6907.
Saito S, Suzuki K, Taguchi A, Ihara M et al. (total 37 authors) Efficacy and safety of cilostazol in mild cognitive impairment: A randomized clinical trial JAMA Network Open 2023 Dec 1;6(12):e2344938.
Taguchi A, Okinaka Y, Takeda A, Okamoto T, Boltze J, Clausen C, Gul S, Activation of neurogenesis in the hippocampus is a novel therapeutic target for Alzheimer’s disease. Neuroprotection. 2023 Dec;1(2):139-142.
Ogawa Y, Akamatsu R, Fuchizaki A, Kazuta Y, Orie S, Tanaka M, Kikuchi-Taura A, Kimura T, Taguchi A, Gap junction-mediated transport of metabolites between stem cells and vascular endothelial cells, Cell Transplantation, 2022 Jan-Dec:31:9636897221136151.
Takeuchi Y, Saino O, Okinaka Y, Ogawa Y, Akamatsu R, Kikuchi-Taura A, Kataoka Y, Maeda M, Gul S, Claussen C, Boltze J, Taguchi A. Increased RNA transcription of energy source transporters in circulating white blood cells of aged mice. Front. Aging 2022. Feb 3;14:759159. doi: 10.3389/fnagi.2022.759159.
Kikuchi-Taura A, Okinaka Y, Saino O, Takeuchi Y, Ogawa Y, Kimura T, Gul S, Claussen C, Boltze J, Taguchi A. Gap junction-mediated cell-cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke Stem cells 2021. Mar 11. Stem cells doi: 10.1161/STROKEAHA.119.028072.
Takeuchi Y, Okinaka Y, Ogawa Y, Kikuchi-Taura A, Kataoka Y, Gul S, Claussen C, Boltze J, Taguchi A. Intravenous Bone Marrow Mononuclear Cells Transplantation in Aged Mice Increases Transcription of Glucose Transporter 1 and Na+/K+-ATPase at Hippocampus Followed by Restored Neurological Functions. Front. Aging 2020 Jun 11. doi: 10.3389/fnagi.2020.00170.
Kikuchi-Taura A, Okinaka Y, Takeuchi Y, Ogawa Y, Maeda M, Kataoka Y, Yasui T, Kimura T, Gul S, Claussen C, Boltze J, Taguchi A. Bone marrow mononuclear cells activate angiogenesis via gap junction mediated cell-cell interaction. Stroke. 2020; 51(4):1279-1289.
Okinaka Y, Kikuchi-Taura A, Takeuchi Y, Ogawa Y, Boltze J, Gul S, Claussen C, Taguchi A. Clot-Derived Contaminants in Transplanted Bone Marrow Mononuclear Cells Impair the Therapeutic Effect in Stroke. Stroke. 2019; 50(10):2883-289
