Hiroaki WAKE
moonshot_isa_master
氏名Name
Hiroaki WAKE
所属・職名Affiliation, Title, etc.
Professor
Department of Anatomy and Molecular Cell Biology
Nagoya University Graduate School of Medicine
研究室HPWebsite
一言メッセージShort Message
I would like to approach dementia from a neurophysiological perspective.
本プロジェクトでの研究概要Outline of the research in this project
In Alzheimer’s disease and other dementias, immune inflammation in the brain leads to the loss of physiological diversity among microglia, immune cells. Consequently, their response to the disease involves a shift towards disease-related subtypes. Therefore, comprehensively understanding the diversity of these microglia, the process of transitioning to disease subtypes, the physiological functions lost during this transition, and the responses to disease will provide insights into the contribution of microglia to disease progression.
By elucidating these aspects, we can comprehensively elucidate the role of microglia in disease. Furthermore, employing organic synthesis technology to deliver drugs specifically to microglia enables in vivo evaluation using positron emission tomography (PET) and magnetic resonance imaging (MRI) to serve as biomarkers for disease states. This approach also facilitates the development of novel therapeutic strategies targeting microglia.
これまで主な研究内容Outline of main research so far
Focusing on microglia and oligodendrocytes, the brain's immune cells among glial cells, we have shown that this occurs in a neural activity-dependent manner by visualizing the local translation of myelin basic protein to the task of controlling neural circuit activity (Wake et al., 2011, Wake et al., 2015).This led to further studies of the neuronal circuitry and learning abnormalities that result from impaired activity-dependent myelination and its lipid changes (Kato et al., 2020,2023). We continue to elucidate the physiological functions of microglia, including their contribution to synapse formation during development (Miyamoto et al., 2016), the contribution of microglial projection dynamics to synaptic plasticity, their involvement in blood-brain barrier permeability in response to systemic inflammation (Haruwaka et al. 2019), and mechanisms that modulate synaptic activity and contribute to neuronal circuit synchrony (Akiyoshi et al., 2018, Badimon et al., 2020). We have suggested that disruption of these physiological functions results in psychiatric disorders (Wake et al., 2013), and have contributed to the formation and development of this field. We have also succeeded in developing a two-photon holographic microscope by establishing medical-engineering collaboration (Quan et al., 2018, Quan et al., 2022) and clarified the formation basis of neural circuits responsible for pain (Okada et al., 2021). We are also currently focusing on the mechanisms of integration of sensory information processing, especially plasticity between different senses, and are clarifying the circuit mechanisms and microglial involvement (Hashimoto et al, 2023) related to visual and tactile information processing switches in cortical visual cortex.
主な経歴・受賞歴等Career, Awards, etc.
- ２００１年
- 名古屋市立大学医学部医学科卒業
- ２００７年
- 名古屋市立大学大学院医学研究科修了 （博士(医学)）取得
- ２００７年
- 生理学研究所CREST研究員
- ２００９年
- 米国国立衛生研究所 Visiting Fellow
- ２０１２年
- 自然科学研究機構 基礎生物学研究所 助教
- ２０１３年
- さきがけ研究員(兼任)
- ２０１４年
- 自然科学研究機構 生理学研究所 准教授
- ２０１６年
- 神戸大学大学院医学研究科 システム生理学分野 教授
- ２０１９年１１月
- 名古屋大学大学院医学研究科 機能形態学講座 分子細胞学 教授
神戸大学 先端融合研究環 特命教授 （兼任・クロスアポイント） - ２０２１年９月
- 名古屋大学大学院医学研究科 機能形態学講座 分子細胞学 教授
自然科学研究機構 生理学研究所 多細胞回路動態研究部門
教授 （兼任・クロスアポイント）
神戸大学 先端融合研究環 特命教授 （兼任・クロスアポイント） - ２０２２年９月
- 名古屋大学大学院医学研究科 機能形態学講座 分子細胞学 教授
自然科学研究機構 生理学研究所 多細胞回路動態研究部門
教授 （兼任・クロスアポイント）
神戸大学 次世代光散乱イメージングセンター 特命教授 （兼任・クロスアポイント）
専門分野
神経科学、神経生理学
受賞歴
- 平成2012年
- Fellows Award for Research Excellence in NIH
- 平成2014
- 文部科学大臣表彰 若手科学賞
Professional experience
- 2001-2003
- Residency (Neurology), Nagoya City University Hospital, Nagoya, Japan
- 2007-2008
- Research Fellow, National Institute for Physiological Sciences, Okazaki, Japan
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency - 2009-
- Visiting Fellow, National Institute of Health, National Institute of Child
Health and Human Development Nervous System Development & Plasticity Section - 2010-2012
- Supplemental Visiting Fellow, National Institute of Health, National Institute of Child Health and Human Development Nervous System Development & Plasticity Section,
Postdoctoral fellowship for Research Abroad, Japan Society for the Promotion of Science. - 2012-2014
- Assistant Professor, Division of Brain Circuits, National Institute for basic biology, National Institutes of Natural Sciences, Okazaki, Japan
Visiting Lecturer, Nagoya City University, Nagoya, Aichi, Japan - 2013.10-
- Assistant Professor, Division of Brain Circuits, National Institute for basic biology,
National Institutes of Natural Sciences, Okazaki, Japan
PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi,Saitama, Japan - 2014-2016
- Associate Professor, Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan
PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi,Saitama, Japan - 2016-2019
- Professor, Division of System Neuroscience. Kobe University of Graduate School of Medicine, Kobe, JAPAN
PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, Japan
Professor, Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan - 2017-2019
- Professor, Division of System Neuroscience. Kobe University Graduate School of Medicine, Kobe, JAPAN
- 2019.4-
- Professor, Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Specially Appointed Professor, Organization for Advanced and Integrated research, Kobe University, Kobe, Japan - Professor, Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Professor, Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, National Institute of Natural Sciences (Cross appointment)
Specially Appointed Professor, Organization for Advanced and Integrated research, Kobe University, Kobe, Japan
2021.9-
Awards and honors
- 2014
- The Young Scientists’ Prize
The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology - 2011
- Fellows Award for Research Excellence in NIH
