Satoko Koganemaru
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氏名Name
Satoko Koganemaru
所属・職名Affiliation, Title, etc.
Department of Rehabilitation Medicine, Osaka Medical and Pharmaceutical University,
Associate Professor
Department of Regenerative Systems Neuroscience, Human Brain Research Center,
Graduate school of Medicine Kyoto University
Part-time researcher
研究室HPWebsite
一言メッセージShort Message
Our advanced rehabilitation enables recovery of any disabled function.
本プロジェクトでの研究概要Outline of the research in this project
Our project aims to develop an ensemble brain stimulation method that stimulates multiple areas of the brain as neuromodulation to enhance reserver function. This will lead to the development of neuromodulation methods useful for improving cognitive function. After confirming the effect in healthy subjects, we aim to apply the method to diseased brains to enhance cognitive and motor functions. In addition, an experimental evaluation system will be developed to measure the ability of dementia patients to perform a double task by modulating brain function networks with non-invasive brain stimulation (joint research with Matsumoto group). We will also support the introduction of transcranial focused ultrasound stimulation (TUS) at Kyoto University, which is capable of deep brain stimulation including the hippocampus and other areas. An evaluation system of cortical-deep brain network function is developing by using the TMS-EEG recording as an evaluation method for the brain stimulation interventions. While preliminarily performing the clinical application of the ensemble brain stimulation to diseased brains, we will propose its translation to primate models (in collaboration with the Higo Group).
これまで主な研究内容Outline of main research so far
As a physiatrist specialized for rehabilitation medicine, I have seen many patients with functional disorders in clinical practice. Then, I have focused on brain plasticity, which is the basis of recovery from functional disorders, and have conducted research on functional enhancement and functional recovery in healthy subjects and patients. Now, we are developing a hybrid rehabilitation method that combines noninvasive brain stimulation methods (transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), etc.) with rehabilitation therapy as an intervention method to enhance brain plasticity and increase the effectiveness of rehabilitation therapy. We have also developed the closed-loop stimulation in collaboration with the engineering researchers, in which brain stimulation is coupled with peripheral movements to induce associative plasticity. It has enabled functional recovery even in a patient with intractable dysfunction. We are also analyzing the neural basis of functional enhancement and functional recovery using EEG, EMG, fMRI, and other techniques to lead development of further functional recovery methods.
主な経歴・受賞歴等Career, Awards, etc.
- 2005
- Graduated from School of Medicine, Kyoto University, Japan
- 2010
- Completed PhD in Rehabilitation Science, Higher Neural Control Systems, Graduate School of Medicine, Hyogo Medical University, Japan
- 2013
- JSPS Postdoctoral Research Fellow, Graduate School of Medicine, Kyoto University, Japan
- 2017
- Assistant Professor, Department of Rehabilitation, Hokkaido University Hospital, Japan
- 2019
- Associate Professor, Department of Physiology, School of Medicine, Dokkyo Medical University, Japan
- 2021
- Specific Associate Professor, Department of Regenerative Systems Neuroscience, Human Brain Research Center, Graduate School of Medicine, Kyoto University
- 2024-Present,
- Associate Professor, Department of Rehabilitation Medicine,
Osaka Medical and Pharmaceutical University
- 2017
- Received the 7th Encouragement Award from the Japanese Society of Clinical Neurophysiology
主要業績Major Publications
Yamashita H, Yamaoka T, Shimomura R, Ichimura S, Murata Y, Itoh A, Mima T, Koganemaru S.Prog Rehabil Med. 2025 Jan 16;10:20250002. doi: 10.2490/prm.20250002.
Omae E, Shima A, Tanaka K, Yamada M, Cao Y, Nakamura T, Hoshiai H, Chiba Y, Irisawa H, Mizushima T, Mima T, Koganemaru S.Front Hum Neurosci. 2024 Feb 22;18:1297683. doi: 10.3389/fnhum.2024.1297683.
Swallow-related Brain Activity in Post-total Laryngectomy Patients: A Case Series Study.
Ogawa A, Koganemaru S, Takahashi T, Takemura Y, Irisawa H, Goto K, Matsuhashi M, Mima T, Mizushima T, Kansaku K.Prog Rehabil Med. 2023 Sep 1;8:20230026. doi: 10.2490/prm.20230026.
Nojima I, Horiba M, Sahashi K, Koganemaru S, Murakami S, Aoyama K, Matsukawa N, Ono Y, Mima T, Ueki Y.J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):938-944. doi: 10.1136/jnnp-2022-329966.
Shimomura R, Shibata S, Koganemaru S, Minakuchi M, Ichimura S, Itoh A, Shimotake K, Mima T.Brain Stimul. 2023 May-Jun;16(3):933-935. doi: 10.1016/j.brs.2023.05.024. Epub 2023 May 29.
Shibata S, Koganemaru S, Mima T.Prog Rehabil Med. 2023 May 25;8:20230015. doi: 10.2490/prm.20230015.
Shima A, Miyake T, Tanaka K, Ogawa A, Omae E, Nagamori Y, Miyata Y, Ohata K, Maki T, Ono Y, Mima T, Takahashi R, Koganemaru S.Front Hum Neurosci. 2023 Jan 27;17:1082556. doi: 10.3389/fnhum.2023.1082556.
Koganemaru S, Mizuno F, Takahashi T, Takemura Y, Irisawa H, Matsuhashi M, Mima T, Mizushima T, Kansaku K.Front Hum Neurosci. 2021 Nov 26;15:643454. doi: 10.3389/fnhum.2021.643454.
Gait-Synchronized Rhythmic Brain Stimulation Improves Poststroke Gait Disturbance: A Pilot Study.
Koganemaru S, Kitatani R, Fukushima-Maeda A, Mikami Y, Okita Y, Matsuhashi M, Ohata K, Kansaku K, Mima T.Stroke. 2019 Nov;50(11):3205-3212. doi: 10.1161/STROKEAHA.119.025354.
Neurofeedback Control of the Human GABAergic System Using Non-invasive Brain Stimulation.
Koganemaru S, Mikami Y, Maezawa H, Ikeda S, Ikoma K, Mima T.Neuroscience. 2018 Jun 1;380:38-48. doi: 10.1016/j.neuroscience.2018.03.051.
Recovery of upper-limb function due to enhanced use-dependent plasticity in chronic stroke patients.
Koganemaru S, Mima T, Thabit MN, Ikkaku T, Shimada K, Kanematsu M, Takahashi K, Fawi G, Takahashi R, Fukuyama H, Domen K.Brain. 2010 Nov;133(11):3373-84. doi: 10.1093/brain/awq193.
Human motor associative plasticity induced by paired bihemispheric stimulation.
Koganemaru S, Mima T, Nakatsuka M, Ueki Y, Fukuyama H, Domen K.J Physiol. 2009 Oct 1;587(Pt 19):4629-44. doi: 10.1113/jphysiol.2009.174342.
